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The odds ratio for vomiting with cagrilintide versus semaglutide or liraglutide was 0.38, meaning cagrilintide caused vomiting at roughly one-third the rate

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The presence of multiple PACAP isoforms, as well as a family of related receptors that also recognize vasoactive intestinal peptide (VIP), renders generation of a PACAP-specific antagonist highly challenging (113)