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2.2 Lactate shuttle Lactate, the terminal glycolytic metabolite, functions as a versatile molecular shuttle—intracellularly, intercellularly, and systemically—modulating cellular bioenergetics and redox equilibrium while accumulating across tissues via circulatory transport ( The aforementioned glycolytic reprogramming drives profound lactate and proton accumulation

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Knockdown of FPN1 can promote ferroptosis in Alzheimer’s disease (AD) and induce AD-like hippocampal atrophy and memory deficits