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3 Urolithin A and sleep: current evidence For this mini-review, we utilized a hypothesis-based scoping review method where we conducted a search on PubMed, Scopus and Ovid utilizing the terms “urolithin A” and “sleep,” “urolithin A” and “circadian,” and “urolithin A” and “serotonin or tryptophan.” Our inclusion criteria were (1) original research articles, (2) published in English, (3) utilizing isolated urolithin A (no mixtures or parent polyphenols) and (4) including at least one outcome relevant to sleep or sleep-related biological mechanisms, with no constraints on publication date

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But its gastrointestinal applications have been studied from the beginning — protection against gastric lesions, reversal of NSAID damage, healing of intestinal anastomoses, reduction of inflammatory bowel pathology