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In addition, high levels of VEGF and HIF-1α are linked with resistance to therapy and metastatic progression in clinical settings

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Decreasing the ratio of more oxidizable PUFAs to less oxidizable monounsaturated fatty acids (MUFAs) is sufficient to convert cells from ferroptosis sensitive to ferroptosis resistant 28,98–101 whereas increasing the PUFA to MUFA ratio can have the opposite effect 22,77