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Rather, a summary of the types of organic compounds listed by Chasseaud is provided as representative of electrophilic xenobiotics that generate mercapturates when administered to experimental animals (rabbits and rats have been most extensively tested): halogenated benzenes, halogenated nitrobenzenes, other arylnitro compounds, chloro- S -triazines (herbicides), phenoltetrabromophthaleins, aralkyl halides, alkyl and alicyclic halides, sulfates and nitro compounds, allyl compounds, alkyl methanesulfonates, organophosphorus compounds, polycyclic aromatic hydrocarbons (via arene oxides), various α,β-unsaturated compounds (esters, aldehydes, ketones, lactones, nitriles, nitro compounds, and sulfones), arylamines, arylhydroxylamines, carbamates, and related compounds

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as a result, surfactant production decreases markedly, which in turn causes alveolar fluid accumulation leading to alveolar collapse and ARDS (Matthay and Zemans, 2011

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