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Conversely, the HIF-1α inhibitor 2ME2 effectively promotes osteoclast ferroptosis and prevents ovariectomy-induced OP in rats (103) that the expression of NADPH oxidase 4 (NOX4) is elevated in OP mice and patients, and NOX4 overexpression drives osteoblast ferroptosis and subsequently causes bone loss in OP mice

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2020 Ghezzi,P Role of glutathione in immunity and inflammation in the lung Int J Gen Med