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Agents that show efficacy at reversing established physical dependence include, L-histidine and histamine receptor sub-type agonists, melatonin, the antioxidant quercetin, the serotonin-reuptake inhibitor, fluoxetine, nitric oxide synthase inhibitors, Ca 2+ -calmodulin-dependent protein kinase II inhibitors, the β 2 -AR antagonist, butoxamine, adrenomedullin receptor antagonists, dopamine D2 receptor antagonists, ATP-dependent K + -channel modulators, and allosteric modulators of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) glutamate receptors 36,54

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