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However, IL-6 also dampens the inflammatory response through its activation of IL-10, a potent anti-inflammatory cytokine.[31] Hyperthermia induces a large increase in circulating IL-6 and, potentially, a reciprocal release of IL-10.[32] The role of IL-6, which can be robustly activated by muscle in the context of exercise, may be more complex than simple inflammatory mediator: as a "myokine," it is also necessary for the insulin-sensitizing effects of exercise.[33] ​ Health benefits associated with sauna use ​ Cardiovascular health ​ Heat exposure induces protective responses against the deleterious biological processes that drive cardiovascular disease and related disability