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2018;13 doi: 10.1371/journal.pone.0195151

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An in vitro experiment showed that lutein could effectively alleviate the senescence of mesenchymal stem cells (MSCs) through suppressing the inflammation of senescent MSCs and showed powerful anti-aging potential in other tissues and organs probably by downregulating the levels of ROS and inflammation, and the underlying mechanisms were the downregulation of nuclear factor kappa-B (NF-κB) and NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) and the upregulation of the Clock gene’s expression [49]