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The stomach produces it, which may be part of why it has such a broad cytoprotective profile: the gastric mucosa lives in a uniquely hostile environment and regenerates continuously

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Although earlier studies did not show the interaction between S100A2 and RAGE, recent studies showed a micromolar affinity and strict calcium-dependent interaction between S100A2 and RAGE via the V-domain of RAGE (64) ( Figure 3 )