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A second region, located in the short cytoplasmic tail, is a CXC motif that mediates the interaction with lymphoid cell kinase (LCK or p56LCK) necessary for T cell activation (Laing et al., The CSD has been demonstrated to be reduced during the process of T-cell signaling, and its reduction is also co-opted during entry of the HIV viral envelope glycoprotein (gp120) into the cell

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doi: 10.3389/fphar.2023.1102888