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Clark 5 , David Liebeskind 6 , Ryan McTaggart 7 1 Revalesio, Tacoma, United States, 2 Northwestern University, Feinberg School of Medicine, Chicago, United States, 3 University of Pennsylvania, Philadelphia, United States, 4 Houston Methodist Hospital, Houston, United States, 5 Oregon Stroke Ctr at OHSU, Portland, United States, 6 University of California Los Angeles, Los Angeles, United States, 7 Rhode Island Hospital, Brown University, Providence, United States Background and Aims: RNS60, an experimental cytoprotective drug, showed preliminary signs of efficacy in the proof-of-concept Phase 2 RESCUE trial in participants with acute ischemic stroke 6), early antiplatelet use was associated with improved functional outcomes on mRS (0.85, 0.76-0.95) and less 7-day NIHSS deterioration (0.63, 0.41-0.98)