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You should contact your GP or seek specialist referral if you are experiencing: Unexplained weight gain or difficulty losing weight despite lifestyle changes Symptoms that may suggest growth hormone deficiency , such as persistent fatigue, reduced muscle mass, increased abdominal fat, or low mood — formal biochemical testing is required before any treatment is initiated Poorly controlled blood glucose or a new diagnosis of type 2 diabetes Interest in weight-management medicines , to discuss licensed options available through NHS or regulated private pathways — access to weight-management pharmacotherapy on the NHS is typically via specialist weight management services, subject to local eligibility criteria Seek urgent medical attention — via NHS 111 or, if necessary, 999 — if you experience severe or persistent abdominal pain (which may indicate pancreatitis), signs of a serious allergic reaction, chest pain or palpitations, or symptoms of diabetic ketoacidosis (extreme thirst, frequent urination, confusion, or vomiting)
