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The aforementioned study elucidates that the inhibition of succinate accumulation and the attenuation of mitochondrial ROS generation serve as potential therapeutic targets for diseases induced by ischemia-reperfusion injuries and related pathological conditions

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In conclusion, our study revises the traditional view of GSH as a global protective antioxidant against protein oxidation under physiological condition and demonstrates that GSH depletion through enhanced degradation leads to selective protein oxidation