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GIP is also implicated in nausea attenuation, which may be why GLP-1/GIP dual agonists like tirzepatide have a slightly better GI tolerability profile than pure GLP-1 agonists

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However, because AOD-9604 does not affect appetite or insulin sensitivity, having breakfast immediately after administration does not appear to interfere with the peptide’s fat tissue effects, making timing more flexible than with compounds that rely on specific insulin or glucose states