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Activated caspase 9 then activates caspases 3 and 7, which ultimately drive the apoptotic process

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Collectively, these sequences share a conserved metal binding site conforming to a DxHx 10 Hx 2 (H/E) motif in the α5 helix that defines an interfacial site between the two subunits of the dimer, and an additional metal binding site harboring a CxC motif in the α3 helix (Figure 10B)